Iridoids from Pedicularis verticillata and Their Anti‐Complementary Activity |
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Authors: | Ming‐Hui Shao Wei Dai Si‐Wen Yuan Yan Lu Dao‐Feng Chen Qi Wang |
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Affiliation: | 1. Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, School of Pharmacy, Shihezi University, Shihezi, P. R. China;2. Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, P. R. China |
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Abstract: | Three new iridoids named as pediverticilatasin A – C ( 1 – 3 , resp.), together with five known iridoids ( 4 – 8 , resp.) were isolated from the whole plants of Pedicularis verticillata. The structures of three new compounds were identified as (1S,7R)‐1‐ethoxy‐1,5,6,7‐tetrahydro‐7‐hydroxy‐7‐methylcyclopenta[c]pyran‐4(3H)‐one ( 1 ), (1S,4aS,7R,7aS)‐1‐ethoxy‐1,4a,5,6,7,7a‐hexahydro‐7‐hydroxy‐7‐methylcyclopenta[c]pyran‐4‐carboxylic acid ( 2 ), (1S,4aS,7R,7aS)‐1‐ethoxy‐1,4a,5,6,7,7a‐hexahydro‐7‐hydroxy‐7‐methylcyclopenta[c]pyran‐4‐carbaldehyde ( 3 ). Their structures were elucidated on the basis of spectroscopic methods and compared with the NMR spectra data in the literature. All compounds were evaluated for their anti‐complementary activity on the classical pathway of the complement system in vitro. Among which, compounds 1 , 3 , and 6 exhibited anti‐complementary effects with CH50 values ranging from 0.43 to 1.72 mm , which are plausible candidates for developing potent anti‐complementary agents. |
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Keywords: |
Pedicularis verticillata
Scrophulariacea iridoids anti‐complementary activity |
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