Six New Polyhydroxysteroidal Glycosides,Anthenosides S1 – S6, from the Starfish Anthenea sibogae |
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Authors: | Alla A Kicha Dinh T Ha Natalia V Ivanchina Timofey V Malyarenko Anatoly I Kalinovsky Pavel S Dmitrenok Svetlana P Ermakova Olesya S Malyarenko Nguyen A Hung Tran T T Thuy Pham Q Long |
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Institution: | 1. G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia;2. Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, Cau Giay, Hanoi, Vietnam;3. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Cau Giay, Hanoi, Vietnam |
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Abstract: | Six new polyhydroxysteroidal glycosides, anthenosides S1 – S6 ( 1 – 6 ), along with a mixture of two previously known related glycosides, 7 and 8 , were isolated from the methanolic extract of the starfish Anthenea sibogae. The structures of 1 – 6 were established by NMR and HR‐ESI‐MS techniques as well as by chemical transformations. All new compounds have a 5α‐cholest‐8(14)‐ene‐3α,6β,7β,16α‐tetrahydroxysteroidal nucleus and differ from majority of starfish glycosides in positions of carbohydrate moieties at C(7) and C(16) ( 1 – 4 , 6 ) or only at C(16) ( 5 ). The 4‐O‐methyl‐β‐d ‐glucopyranose residue ( 2 ) and Δ24‐cholestane side chain ( 3 ) have not been found earlier in the starfish steroidal glycosides. The mixture of 7 and 8 slightly inhibited the proliferation of human breast cancer T‐47D cells and decreased the colony size in the colony formation assay. |
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Keywords: |
Anthenea sibogae
starfish polyhydroxysteroids glycosides clonogenic assay |
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