| [B2-Lys]-胰岛素的制备与性质 |
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| 引用本文： | 徐明华,叶莺,张新堂,朱尚权.[B2-Lys]-胰岛素的制备与性质[J].中国生物化学与分子生物学报,1992,8(4):410-413. |
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| 作者姓名： | 徐明华 叶莺 张新堂 朱尚权 |
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| 作者单位： | 中国科学院上海生物化学研究所，中国科学院上海生物化学研究所，中国科学院上海生物化学研究所，中国科学院上海生物化学研究所 上海 200031，上海 200031，上海 200031，上海 200031 |
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| 摘 要： | 本文报道了用化学半合成途径从天然猪胰岛素制备B2-Lys]-胰岛素的过程。人胎盘细胞膜胰岛素受体结合试验表明:B2-Lys]-胰岛素的受体结合能力只有天然胰岛素的80％,降兔血糖作用与时间关系的结果表明它没有长效作用。本文还对这些结果进行了讨论。
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| 关 键 词： | 胰岛素 [B2-Lys]-胰岛素 受体结合 降血糖作用 |
| 收稿时间： | 1992-08-20 |
Preparation and Properties of [B2-Lys] Insulin |
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| Xu,Ming-hua Ye,Ying Zhang,Xin-tang Zhu,Shang-quan.Preparation and Properties of [B2-Lys] Insulin[J].Chinese Journal of Biochemistry and Molecular Biology,1992,8(4):410-413. |
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| Authors: | Xu Ming-hua Ye Ying Zhang Xin-tang Zhu Shang-quan |
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| Institution: | (Shanghai Institute of Biochemistry,Chinese Academy of Sciences,Shanghai 200031 |
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| Abstract: | The semisynthetic method for preparation of B2-Lys]-insulin from native porcine insulin has been described in this paper.The insulin receptor binding assay on human placental membrane showed that the receptor binding Capacity of B2-Lys]-insulin was only 80% that of the native insulin, which is quite different from the increased insulin receptor binding capacity of B3-Lys]-insulin.It was observed that the replacement of B2-Val by Lys in insulin molecule did not prolong its effect on lowering blood glucose in rabbit.The effect of N-terminal sequence of insulin B-chain on receptor binding has been discussed. |
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| Keywords: | Insulin [B2-Lys]-insulin Receptor binding Lowing blood glucose |
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