Studies on a leukocyte elastase inhibitor present in the culture medium of inflamed synovial tissue |
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| Authors: | M E Englert M J Landes J E Birnbaum A L Oronsky S S Kerwar |
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| Affiliation: | Connective Tissue and Arthritis Research Unit Metabolic Disease Research Section, Medical Research Division, American Cyanamid Company, Lederle Laboratories, Pearl River, New York 10965 USA |
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| Abstract: | The spent medium of cultured inflamed synovial tissue contains a potent inhibitor of leukocyte elastase. This leukocyte elastase inhibitor has no effect on leukocyte cathepsin G and pancreatic elastase is only marginally affected. The inhibitor is a glycoprotein, stable to heat, acid and reductive alkylation. Pretreatment of the inhibitor with either trypsin or chymotrypsin results in its inactivation. |
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| Keywords: | To whom correspondence should be addressed. |
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