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Antimutagenesis of multiphytoadaptogene in yeast Saccharomyces |
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| Authors: | O N Kurennaya R V Karpova O A Bocharova I V Kazeev E V Bocharov V G Korolev |
| Institution: | 1. Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia 2. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia 3. Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, 125315, Russia 4. Konstantinov St. Petersburg Nuclear Physics Institute, Leningrad oblast, Gatchina, 188300, Russia |
| Abstract: | Multiphytoadaptogene (MPA) consists of plant extracts components including adaptogenes. Genotoxicity analysis revealed the antimutagenic activity of MPA. MPA decreased the direct mutations frequency in ADE4-ADE8 loci induced by UV radiation and nitrous acid by 3.7 and 33 times, respectively. The lethal effect of UV radiation was inhibited when the preparation preparation MFA was used on complete medium with ethanol. MPA had no effect on replicative mutagenesis. At the same time it depressed mutagenesis caused by repair errors. The data obtained suggest the antimutagenic activity of multiphytoadaptogene is associated with postreplicative repair activation. |
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