Modeling cell entry into a micro-channel |
| |
Authors: | Leong Fong Yew Li Qingsen Lim Chwee Teck Chiam Keng-Hwee |
| |
Institution: | (1) Department of Chemical and Biological Engineering, University of British Columbia, Vancouver, BC, Canada, V6T 1Z3;(2) Department of Mathematics, University of British Columbia, Vancouver, BC, Canada, V6T 1Z2; |
| |
Abstract: | Cell entry into a micro-channel has potential applications in cell sorting and cancer diagnostics. In this paper, we numerically
model breast cancer cell entry into a constricted micro-channel. Our results indicate that the cell velocity decreases during
entry and increases after entry, an observation in agreement with experiments. We found that the cell entry time depend strongly
on the cortical stiffness and is minimum at some critical cortical elasticity. In addition, we found that for the same entry
time, a stiff nucleus is displaced toward the cell front, whereas a viscous nucleus is displaced toward the rear. In comparison,
the nucleus is less sensitive to the viscosity of the cytoplasm. These observations suggest that specific intra-cellular properties
can be deduced non-invasively during cell entry, through the inspection of the nucleus using suitable illumination techniques,
such as fluorescent labeling. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|