A highly sensitive peroxidase-antiperoxidase method for detection of H-Y antigen on cultivated human fibroblasts |
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Authors: | U. Müller K. Bross |
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Affiliation: | (1) Institut für Humangenetik und Anthropologie der Universität, Albertstr.11, D-7800 Freiburg, Federal Republic of Germany;(2) Medizinische Universitätsklinik, Hugstetterstr. 55, D-7800 Freiburg, Federal Republic of Germany |
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Abstract: | Summary A peroxidase-anti-peroxidase method for the detection of H-Y antigen at the single cell level is described. The efficiency of the test was examined in cultivated fibroblasts derived from control subjects and from XX males and a true hermaphrodite. For comparison, H-Y antigen was determined in blood cells of the same probands using the cytotoxic test. The finding of H-Y positive fibroblasts in the intersex patients has implications for the origin of these disorders. |
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