Hypotensive action of coumarin glycosides from Daucus carota. |
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Authors: | A H Gilani,E Shaheen,S A Saeed,S Bibi,M Irfanullah Y" >Sadiq,S Faizi |
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Affiliation: | Department of Physiology and Pharmacology, The Aga Khan University Medical College, Karachi, Pakistan. anwar.gilani@aku.edu |
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Abstract: | Daucus carota (carrot) has been used in traditional medicine to treat hypertension. Activity-directed fractionation of aerial parts of D. carota resulted in the isolation of two cumarin glycosides coded as DC-2 and DC-3. Intravenous administration of these compounds caused a dose-dependent (1-10 mg/kg) fall in arterial blood pressure in normotensive anaesthetised rats. In the in vitro studies, both compounds caused a dose-dependent (10-200 microg/ml) inhibitory effect on spontaneously beating guinea pig atria as well as on the K+ -induced contractions of rabbit aorta at similar concentrations. These results indicate that DC-2 and DC-3 may be acting through blockade of calcium channels and this effect may be responsible for the blood pressure lowering effect of the compounds observed in the in vivo studies. |
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