Gene expression in Drosophila: post-translational modification of aldehyde oxidase and xanthine dehydrogenase. |
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Authors: | Victoria Finnerty Margaret McCarron George B. Johnson |
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Affiliation: | (1) Department of Biology, Emory University, 30322 Atlanta, Georgia;(2) Genetics and Cell Biology, University of Connecticut, 06268 Storrs, Connecticut;(3) Department of Biology, Washington University, 63130 St. Louis, Missouri, USA |
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Abstract: | Summary Maroon-like homozygotes are completely deficient for xanthine dehydrogenase (XDH) and aldehyde oxidase (AO), however ma-l is not a structural locus for either enzyme. Quantitative immunoelectrophoresis of ma-l and wild type extracts suggests that the ma-l function must be post-translational. To determine whether the ma-l function involves some direct physical changes in XDH and/or AO the enyzmes were characterized with respect to temperature sensitivity and behavior in gel sieving electrophoresis. Since the XDH and AO from complementary ma-l heterozygotes is more thermolabile and different in shape from wild type XDH and AO, we conclude that ma-l is involved in a post-translational modification of these enzymes. |
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