Depletion of protein kinase C induced by an anti HLA class I monoclonal antibody in phytohemagglutinin activated human T cells |
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Authors: | L Poltronieri E Melloni M Rubini R Selvatici C Mazzilli R Baricordi E Gandini |
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Institution: | Istituto di Genetica Medica, Università degli Studi di Ferrara, Italy. |
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Abstract: | Anti HLA Class I Monoclonal Antibody depletes Protein Kinase C (PKC) to 20% of control value in PHA activated human T cells. The effect is reversible: in 24 hours the enzymatic activity returns to 58% of control value. Removal of antibody from the culture medium increases the rate of recovery. Implications of this finding for the modulation by HLA Class I antigens of the proliferative response of T cells to lectins are discussed. |
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