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Cytogenetic analysis of in vitro fertilization (IVF) failures |
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| Authors: | M. H. E. C. Pieters J. P. M. Geraedts J. C. M. Dumoulin J. L. H. Evers M. Bras F. H. A. C. Kornips P. P. C. A. Menheere |
| Affiliation: | (1) Department of Genetics and Cell Biology, University of Limburg, P.O. Box 616, NL-6200 MD Maastricht, The Netherlands;(2) Department of Obstetrics and Gynaecology, Academic Hospital Maastricht, NL-6200 MD Maastricht, The Netherlands;(3) Department of Clinical Chemistry, Academic Hospital Maastricht, NL-6200 MD Maastricht, The Netherlands |
| Abstract: | Summary Cytogenetic studies were carried out on 150 oocytes obtained in a human in vitro fertilization (IVF) program. Although all cells lacked signs of fertilization at light microscopy, 46 (30.7%) appeared to show cytological evidence of fertilization. At least one-third of these cells (with development arrested before first cleavage) had chromosomal aberrations. An aneuploidy rate of 35% was found in unfertilized oocytes. The results of this study explain some of the fertilization failures and of the failures of postfertilization development. |
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