Loss of transferrin receptors following induced differentiation of HL-60 promyelocytic leukemia cells |
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| Authors: | Chang-Jing G. Yeh M. Papamichael W. Page Faulk |
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| Affiliation: | 1. Blond McIndoe Centre for Transplantation Biology, Queen Victoria Hospital, East Grinstead, Sussex RH19 3DZ, UK;2. Hellenic Anticancer Institute, Papanicolaou Research Center of Oncology and Experimental Surgery, Athens, Greece |
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| Abstract: | Human promyelocytic leukemia (HL-60) and lymphoblastoid (Daudi) cells were studied: for transferrin receptors before and after induced differentiation with dimethyl sulfoxide (DMSO), sodium butyrate or retinoic acid. None of these reagents affected the morphology or presentation of receptors in Daudi cells, but many HL-60 morphologically matured to banded neutrophils and demonstrated a concomitant loss of transferrin binding, suggesting an important role for transferrin receptors in cellular differentiation. |
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