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Intracellular angiotensin II as a regulator of muscle tone in vascular resistance vessels. Pathophysiological implications
Institution:1. Laboratorio de Parasitología Molecular, Pontificia Universidad Javeriana, Carrera 7 No. 43-82, Bogotá D.C., Colombia;2. Grupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Carrera 7 No. 43-82, Bogotá D.C., Colombia;3. Instituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento, s/n.18016, Granada, Spain;4. Núcleo de Biotecnología Curauma, Pontificia Universidad Católica de Valparaíso, Avenida Universidad 330, Curauma, Valparaíso, Chile;5. Instituto de Arritmias Joseph Brugada, Fundación Clínica Abood Shaio, Diagonal 115A No. 70C-75, Bogotá D.C., Colombia;6. Grupo de Ciencias Básicas Médicas, Facultad de Medicina, Universidad de los Andes, Carrera 1 No. 18A-10, Bogotá D.C., Colombia;7. Departament de Fisicoquímica, Facultat de Farmàcia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain;1. Centre of Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, ON, Canada;2. Department of Biology, Memorial University of Newfoundland, St John’s, NL, Canada;3. Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China;1. College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, 21983, South Korea;2. Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon, 24341, South Korea;3. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam;1. Université de Poitiers, Équipe Récepteurs, Régulations et Cellules Tumorales (2RCT), Pôle Biologie Santé, Bât. B36/B37, UFR Sciences Fondamentales et Appliquées, 1 rue Georges Bonnet TSA, 51106 86073 Poitiers Cedex 9, France;2. Université de Rouen, INSERM U982, Equipe Neuropeptides, survie neuronale et plasticité cellulaire, IRIB, UFR Sciences et Techniques, Place E. Blondel, 76821 Mont-Saint-Aignan, France;3. INRS, Institut Armand-Frappier, 531 boul. des Prairies, Laval, QC H7V 1B7, Canada;4. Université de la Réunion, Stemcis c/o CYROI, 2, rue Maxime Rivière, 97490 Sainte Clotilde, France;1. School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea;2. Charmzone R&D Center, Charmzone Co. LTD., 318 Yeongdong-daero, Gangnam-gu, Seoul 06177, Republic of Korea
Abstract:The influence of intracellular angiotensin II on the regulation of potassium current and membrane potential of smooth muscle cells of mesenteric arteries and its relevance for the regulation of vascular tone was reviewed. The presence of components of the renin angiotensin system (RAS) in different cells of the cardiovascular system, was discussed including their presence in the nuclei and mitochondria. Emphasis was given to the opposite effects of intracellular and extracellular angiotensin II (Ang II) on the regulation of potassium current, membrane potential and contractility of vascular resistance vessels and its implication to vascular physiology and pathology and the possible role of epigenetic factors on the expression of angiotensin II (Ang II) and renin in vascular resistance vessels as well as its possible pathophysiological role in hypertension and other cardiovascular diseases.
Keywords:Intracellular  Extracellular  Angiotensin II  Potassium current  Mesenteric artery myocyte  Rat
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