Neuroprotective effect of ischemic preconditioning via modulating the expression of adropin and oxidative markers against transient cerebral ischemia in diabetic rats |
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| Institution: | 1. Bor State Hospital, Neurology Clinic, Istasyon Street, 51700 Bor, Nigde, Turkey;2. BezmiAlem Vakif University, Vocational School of Health Services, Medical Laboratory Techniques, Adnan Menderes Bulvar?, 34093 Fatih, Istanbul, Turkey;3. Fatih University, Faculty of Engineering, Department of Genetics and Bioengineering, Buyukcekmece Campus, 34500 Buyukcekmece, Istanbul, Turkey;1. Department of Clinical Sciences, Medicine, Lund University, Sölvegatan 19, 22184 Lund, Sweden;2. Graduate School of Medicine, Akita University, Akita, Japan;3. Yutaka Seino Distinguished Center for Diabetes Research, Kensai Electric Power Medical Research Institute, Kobe, Japan;1. Experimental Cardiovascular Research Unit, Clinical Research Center, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden;2. Department of Cardiology, Lund University, Skåne University Hospital, Malmö, Sweden;1. Cardiovascular Division, Lotung Poh-Ai Hospital, Luodong, Taiwan;2. Department of Biomedical Engineering, Chung Yuan Christian University, Chungli, Taiwan;3. Department of Anesthesiology, China Medical University Hospital, Taichung, Taiwan;4. Department of Physiology, China Medical University, Taichung, Taiwan;5. Division of Cardiology, Department of Medicine, Taipei Medical University Wan Fang Hospital, Taipei, Taiwan;1. Department of Medical Physiology, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey;2. Department of Histology and Embryology, Faculty of Medicine, Ayd?n Adnan Menderes University, Ayd?n, Turkey;3. Department of Medical Services and Techniques, Vocational School of Health Services, Sivas Cumhuriyet University, Sivas, Turkey;4. Department of Anatomy, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey |
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| Abstract: | IntroductionIschemic preconditioning (IPreC) can render the brain more tolerant to a subsequent potential lethal ischemic injury. Hyperglycemia has been shown to increase the size of ischemic stroke and worsen the clinical outcome following a stroke, thus exacerbating oxidative stress. Adropin has a significant association with cardiovascular disease, especially with diabetes. In this study, we aimed to evaluate the role of the IPreC due to modulating the expression of adropin and oxidative damage markers against stroke by induced transient middle cerebral artery occlusion (MCAo) in streptozotocin (STZ)-induced diabetic rats.Material-method72 male Spraque Dawley rats were allocated to 8 groups. In order to evaluate alterations of anti/oxidative status and adropin level, we induced transient MCAo seven days after STZ-induced diabetes. Also we performed IPreC 72 h before transient MCAo to assess whether IPreC could have a neuroprotective effect against ischemia-reperfusion injury.ResultsThe general characteristics of STZ-treated rats (STZ) included reduced body weight and elevated blood glucose levels compared to non-diabetic ones. Ischemic preconditioning before cerebral ischemia significantly reduced infarction size compared with the other groups IPreC + MCAo (27 ± 11 mm3) vs. MCAo (109 ± 17 mm3) p < 0.001; STZ + IPreC + MCAo (38 ± 10 mm3) vs. STZ + MCAo (165 ± 45 mm3) p < 0.001, respectively]. The mean total antioxidant status level in IPreC groups was higher than other groups (p ≤ 0.05). Moreover, IPreC considerably decreased mean adropin levels compared with other groups (p ≤ 0.05).ConclusionThe study results supported the neuroprotective effects of ischemic preconditioning in MCA infarcts correlated with the level of oxidative damage markers and adropin. |
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| Keywords: | Transient ischemia Adropin Oxidative stress Preconditioning Neuroprotection |
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