| Neuritin在大鼠脑外伤合并骨折过程中的作用研究 |
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| 引用本文： | 彭方亮,董金波,吴迎波,刘垚炜,张志峰,赵磊. Neuritin在大鼠脑外伤合并骨折过程中的作用研究[J]. 现代生物医学进展, 2011, 11(15): 2854-2857 |
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| 作者姓名： | 彭方亮 董金波 吴迎波 刘垚炜 张志峰 赵磊 |
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| 作者单位： | 1. 新疆石河子大学医学院,新疆石河子,832000
2. 新疆石河子大学医学院第一附属医院骨一科,新疆石河子,832000 |
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| 摘 要： | 目的:研究脑外伤合并股骨骨折的骨痂中Neuritin的表达及血清中变化,探讨中枢神经系统损伤加速对骨折愈合的作用,为临床难治性骨创伤提供新的理论依据。方法:取96只雄性SD大鼠随机分成:A组正常组8只、B组单纯骨折组40只、C组单纯脑外伤组8只及D组骨折合并脑外伤组40只,做股骨骨折和采用脑损伤液压装置建脑损伤模型,术后3、7、14、21、28天取血离心,ELISA法测血清中的Neuritin值。分时间处死B组和D组,取骨痂做切片,行免疫组织化学染色,观测各时间点骨痂中Neuritin的变化和骨折愈合情况。结果:①免疫组织化学染色:骨折愈合过程中血管内皮细胞、软骨细胞及成骨细胞的胞浆中有阳性表达,并显色强。D组1w至3w时的Neuritin阳性细胞百分数均高于B组有显著性统计意义(P<0.05),但4周时(P>0.05)。②血清浓度值:A组值(81.37±1.37),B组、C组、D组3天(94.94±3.77 107.28±3.46 118.35±1.43)逐渐升高,2周达到高峰(110.18±1.48131.89±3.26 161.48±1.46),然后下降,3d至3w时各组有显著性统计意义(P<0.05),4周下降为略高于正常(P>0.05)结论:血清和骨痂中Neuritin的表达显著升高,提示Neuritin可能是大鼠股骨骨折合并脑损伤时促进骨折修复的重要因素一
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| 关 键 词： | 脑外伤 骨折愈合 Neuritin |
Expression of Neuritin in Brain Trauma with Femur Fracture in Rats |
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| PENG Fang-liang,DONG Jin-bo,WU Ying-bo,LIU Yao-wej,ZHANG Zhi-feng,Zhao Lei. Expression of Neuritin in Brain Trauma with Femur Fracture in Rats[J]. Progress in Modern Biomedicine, 2011, 11(15): 2854-2857 |
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| Authors: | PENG Fang-liang DONG Jin-bo WU Ying-bo LIU Yao-wej ZHANG Zhi-feng Zhao Lei |
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| Affiliation: | 1 (1 medicaine college of Shihezi Unversity,Shihezi 832000; 2 Xinjiang.Department of Orthopedics,the First Affiliated Hospital of medicaine college of Shihezi Unversity. Shihezi 832000,Xinjiang,China) |
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| Abstract: | Objective:To analyze the changes in the expression levels of serum Neuritin and Neuritin in callus of femoral fracture after brain injury in SD-rats,and to investigate the relationship and mechanism of central nervous system injury on fracture healing,in order to provide new theoretical foundation for the treatment of refractoriness fracture for clinical selectivity.Methods:A total of ninety-six SD-rats were selected and were randomly divided into four groups:group A,negative control(n=8);group B,brain inju... |
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| Keywords: | Brain injury Fracture healing Neuritin |
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