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| 肠淋巴再灌注加重肠系膜上动脉闭塞性休克大鼠肺部炎症反应 | |
| 引用本文： | 刘争杰,赵自刚,赵永泉. 肠淋巴再灌注加重肠系膜上动脉闭塞性休克大鼠肺部炎症反应[J]. 现代生物医学进展, 2011, 11(16): 3074-3076 |
| 作者姓名： | 刘争杰 赵自刚 赵永泉 |
| 作者单位： | 1. 河北北方学院病理生理学教研室 河北张家口 075000；河北北方学院附属第一医院麻醉科 河北张家口 075000 2. 河北北方学院病理生理学教研室 河北张家口 075000 3. 河北北方学院附属第一医院麻醉科 河北张家口 075000 |
| 基金项目： | 河北省科技支撑计划，张家口市科技攻关计划 |
| 摘 要： | 目的:研究肠系膜淋巴再灌注对肠系膜上动脉闭塞性(SMAO)休克大鼠肺部炎症反应的影响。方法:24只Wistar雄性大鼠均分为4组:SMAO组,MLR组,SMAO+MLR组,SHAM组。再灌注2h后,迅速留取肺组织,一部分制备组织匀浆,检测细胞间粘附分子(ICAM-1)和晚期糖基化产物受体(RAGE)。再另外选取固定位置肺部组织放入中性甲醛中固定,用于测定肺内HMGB1、RAGE的表达。结果:SMAO与SMAO+MLR组肺部组织匀浆ICAM-1、RAGE含量显著高于MLR与SHAM组,且SMAO+MLR组肺组织匀浆的ICAM-1、RAGE含量高于SMAO组。肺部组织内HMGB1和RAGE在MLR组与SHAM组基本不表达,或少量表达,MLR加重了SMAO休克模型中HMGB1和RAGE的表达。结论:MLR加重SMAO休克大鼠肺部炎症反应,进一步证实肠淋巴途径在SMAO休克发病学中具有重要作用,同时证实HMGB1及RAGE在SMAO休克大鼠的炎症失常反应中起重要作用。 |
| 关 键 词： | 肠淋巴再灌注 肠系膜上动脉闭塞性休克 高迁移率族蛋白-1 |
Mesenteric Lymph Reperfusion Aggravates Pulmonary Inflammatory Response in Superior Mesenteric Artery Occlusion Shock Rats |
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| LIU Zheng-jie,ZHAO Zi-gang,ZHAO Yong-quan. Mesenteric Lymph Reperfusion Aggravates Pulmonary Inflammatory Response in Superior Mesenteric Artery Occlusion Shock Rats[J]. Progress in Modern Biomedicine, 2011, 11(16): 3074-3076 | |
| Authors: | LIU Zheng-jie ZHAO Zi-gang ZHAO Yong-quan |
| Affiliation: | (2Δ) (1 Department of Pathophysiology,Hebei North University,Hebei,Zhangjiakou 075000,China;2 Department of Anesthesia,the first affiliated hospital of Hebei North College,Hebei,Zhangjiakou 075000,China) |
| Abstract: | Objective:To investigate the effect of mesenteric lymph reperfusion on pulmonary inflammatory response in superior mesenteric artery occlusion(SMAO) shock rats.Methods:A total of 24 male Wistar rats were randomly divided into four groups:SMAO group,MLR group,SMAO+MLR group,SHAM group.2h after reperfusion,lung tissue were taken,part of which was homogenized for determining intercellular adhesion molecule-1(1CAM-1) and the receptor of advanced glycation end-products(RAGE);At the same time, some fixed lung tis... |
| Keywords: | Superior mesenteric artery occlusion shock Mesenteric lymph reperfusion High mobility group box-1 |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |