| 磷脂酰肌醇3- 激酶对心脏的调节 |
| |
| 引用本文： | 王玉强盛净. 磷脂酰肌醇3- 激酶对心脏的调节[J]. 现代生物医学进展, 2011, 11(13): 2578-2580 |
| |
| 作者姓名： | 王玉强盛净 |
| |
| 作者单位： | 上海交通大学医学院附属第九人民医院,老年科,上海200011 |
| |
| 摘 要： | 磷脂酰肌醇3-激酶(phosphatidylinosito1 3-kinase,PI3K)是体内很多生理过程中起关键作用的信号分子,PI3K介导的信号转导通路调节细胞的增生、分化、凋亡等活动。以往研究较多的是PI3K与肿瘤发生发展的关系,最近很多研究发现PI3K介导的信号转导通路对心脏具有重要的调节功能。本文就近年来关于PI3K的结构和功能以及PI3K对心脏的调节的研究作一综述。
|
| 关 键 词： | PI3K/Akt 信号通路 心肌肥大 心衰 |
Regulation of Phosphoinositide 3-kinases on the Heart |
| |
| WANG Yu-qiang,SHENG Jing. Regulation of Phosphoinositide 3-kinases on the Heart[J]. Progress in Modern Biomedicine, 2011, 11(13): 2578-2580 |
| |
| Authors: | WANG Yu-qiang SHENG Jing |
| |
| Affiliation: | (Department of Gerontics,Shanghai Ninth People,s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China) |
| |
| Abstract: | Phosphoinositide 3-kinases (PI3K)plays an important role in cell responses including cell proliferationl,differentiationand apoptosis.In the past,many studies focused on the effects of PI3K on genesis and development of tumor, however ,in recent years,many researches have revealed that PI3K signaling pathway has significant effects on cardiac regulation.In this review,the structure andfunction of PI3K and its roles in cardiac regulation will be summarized. |
| |
| Keywords: | PI3K/Akt Signaling pathway Myocardial hypertrophy Heart failure |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《现代生物医学进展》浏览原始摘要信息 |
|
点击此处可从《现代生物医学进展》下载全文 |
|
