| 建立“人工面神经技术”恢复周围性面瘫兔的闭眼功能 |
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| 引用本文： | 王宇娟,李克勇,刘景全,许栋岳,芮岳峰.建立“人工面神经技术”恢复周围性面瘫兔的闭眼功能[J].现代生物医学进展,2011,11(15):2828-2831. |
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| 作者姓名： | 王宇娟 李克勇 刘景全 许栋岳 芮岳峰 |
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| 作者单位： | 1. 上海交通大学附属第一人民医院耳鼻咽喉-头颈外科,上海,200080
2. 上海交通大学微纳科学技术研究院微米/纳米加工技术国家级重点实验室薄膜与微细技术教育部重点实验室,上海,200030 |
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| 基金项目： | 国家自然科学基金，国家自然科学基金 |
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| 摘 要： | 目的:建立"人工面神经技术"以恢复单侧周围性面瘫兔的眼轮匝肌闭眼功能,为周围性面瘫提供一种新的治疗手段。方法:制备单侧周围性面瘫兔,建立健侧眼轮匝肌肌电信号采集、中枢信号处理模式识别、患侧电流刺激眼轮匝肌系统。当健侧眼轮匝肌采集的肌电信号经信号识别、提取以及电脑分析判断,符合其闭眼刺激阈值时,即对人工电刺激器发出指令,由刺激电极直接作用于患侧眼轮匝肌,引起眼睑完全闭合结果:以最小电流刺激患侧眼轮匝肌,引起眼睑完全闭合刺激方式为正负矩形波,电流强度为0.30～0.50mA。结论:利用可植入式微机电技术,在单侧周围性面瘫模型建立"人工面神经反射弧",恢复患侧眼轮匝肌闭眼收缩,可维持双侧闭眼功能的对称性和同步性。
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| 关 键 词： | 面神经反射弧 周围性面瘫 面瘫模型 电流刺激 人工电刺激器 |
Establishing "Artificial Facial Nerve" to Recover Eye-closed Function of Rabbit Model with Peripheral Facial Paralysis |
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| WANG Yu-juan,LI Ke-yong,LIU Jing-quan,XU Dong-yue,RUI Yue-feng.Establishing "Artificial Facial Nerve" to Recover Eye-closed Function of Rabbit Model with Peripheral Facial Paralysis[J].Progress in Modern Biomedicine,2011,11(15):2828-2831. |
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| Authors: | WANG Yu-juan LI Ke-yong LIU Jing-quan XU Dong-yue RUI Yue-feng |
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| Institution: | 1.Department of Otolaryngology-Head and Neck Surgery,Shanghai Jiaotong University Affiliated First People’sHospital,Shanghai, 200080,China;2 Research Institute of Micro/Nano Science and Technology Shanghai Jiao Tong University,Shanghai,200080,China) |
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| Abstract: | Objective:To establish artificial facial nerve to recover eye-closed function of rabbit model with half peripheral facial paralysis.Methods:The rabbit model was prepared with half peripheral facial paralysis.The electromyographic(EMG) signal collection,center signal procession,electric current excitation was constructed When EMG signal gathered by gather electrodes was larger than the stimulus threshold of eye-closed,artificial electrical stimulator send out orders to excite directly to musculus orbicularis... |
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| Keywords: | Facial nerve reflex Facial paralysis Facial paralysis model current stimulation Artificial electrical stimulator |
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