Ca2+ release induced by cyclic ADP-ribose |
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Authors: | Galione A White A |
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Institution: | University Department of Pharmacology, Oxford, UK. |
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Abstract: | Cyclic ADP-ribose (cADPR) is the most potent Ca2+-mobilizing agent known. It has been found in many different cell types, where it is synthesized from its precursor NAD+ by ADP-ribosyl cyclases. cADPR binds to Ca2+ channels in the endoplasmic reticulum membrane to activate a Ca2+-release mechanism. This release is itself potentiated by elevated cytoplasmic Ca2+ concentrations. Thus, cADPR may function as an endogenous regulator of Ca2+-induced Ca2+ release, and there is excitement that it may also function as a Ca2+-mobilizing second messenger. |
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