Effect of endothelin-1 on release of arginine-vasopressin from perifused rat hypothalamus |
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| Authors: | M Shichiri Y Hirata K Kanno K Ohta T Emori F Marumo |
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| Institution: | Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan. |
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| Abstract: | Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor peptide with potent pressor activity. We studied the effect of ET-1 on release of arginine-vasopressin (AVP) from perifused rat hypothalamus. ET-1 (10(-10) to 10(-8) M) significantly stimulated AVP release. The ET-1-induced AVP release was completely blocked in the presence of nicardipine. Our results suggest a possible involvement of ET in the regulation of AVP release. |
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