Tetherin Upregulation in Simian Immunodeficiency Virus-Infected Macaques |
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| Authors: | Andrew R Rahmberg William J Neidermyer Jr Matthew W Breed Xavier Alvarez Cecily C Midkiff Michael Piatak Jr Jeffrey D Lifson David T Evans |
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| Institution: | Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, USAa;Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, USAb;SAIC—Frederick, National Cancer Institute at Frederick, Frederick, Maryland, USAc |
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| Abstract: | Here we show that simian immunodeficiency virus (SIV) infection of rhesus macaques results in rapid upregulation of tetherin (BST-2 or CD317) on peripheral blood lymphocytes, including the CD4+ CCR5+ T cell targets of virus infection, with a peak of induction that coincides with peak alpha interferon (IFN-α) levels in plasma, and that tetherin remains above baseline levels throughout chronic infection. These observations are consistent with a role for tetherin in innate immunity to immunodeficiency virus infection. |
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