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Notch1 Receptor Regulates AKT Protein Activation Loop (Thr308) Dephosphorylation through Modulation of the PP2A Phosphatase in Phosphatase and Tensin Homolog (PTEN)-null T-cell Acute Lymphoblastic Leukemia Cells |
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| Authors: | Eric C. Hales Steven M. Orr Amanda Larson Gedman Jeffrey W. Taub Larry H. Matherly |
| Affiliation: | From the Departments of ‡Oncology.;‖Pharmacology, and ;**Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201.;the ¶Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, and ;the §Children''s Hospital of Michigan, Detroit, Michigan 48201 |
| Abstract: | |
| Keywords: | Akt PKB AMP-activated Kinase (AMPK) Leukemia mTOR Myc Notch Pathway PP2A GSI-resistant PTEN-null T-ALL |