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Population differentiation and migration: coalescence times in a two-sex island model for autosomal and X-linked loci |
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| Authors: | Ramachandran Sohini Rosenberg Noah A Feldman Marcus W Wakeley John |
| Affiliation: | a Society of Fellows, Harvard University, Cambridge, MA, USA b Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA c Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA d Center for Computational Medicine and Biology, University Michigan, Ann Arbor, MI, USA e The Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA f Department of Biological Sciences, Stanford University, Stanford, CA, USA |
| Abstract: | Evolutionists have debated whether population-genetic parameters, such as effective population size and migration rate, differ between males and females. In humans, most analyses of this problem have focused on the Y chromosome and the mitochondrial genome, while the X chromosome has largely been omitted from the discussion. Past studies have compared FST values for the Y chromosome and mitochondrion under a model with migration rates that differ between the sexes but with equal male and female population sizes. In this study we investigate rates of coalescence for X-linked and autosomal lineages in an island model with different population sizes and migration rates for males and females, obtaining the mean time to coalescence for pairs of lineages from the same deme and for pairs of lineages from different demes. We apply our results to microsatellite data from the Human Genome Diversity Panel, and we examine the male and female migration rates implied by observed FST values. |
| Keywords: | X chromosome mmlsi47" onclick=" submitCitation('/science?_ob=MathURL& _method=retrieve& _eid=1-s2.0-S0040580908000907& _mathId=si47.gif& _pii=S0040580908000907& _issn=00405809& _acct=C000053510& _version=1& _userid=1524097& md5=cb6da841234ff7cea9602572a4530d2d')" style=" cursor:pointer " alt=" Click to view the MathML source" title=" Click to view the MathML source" > formulatext" title=" click to view the MathML source" >FST Separation of time scales Coalescent |
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