Second messengers involved in the muscarinic control of the heart: the role of the phosphoinositide response |
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| Authors: | John N Hawthorne Sandra H Simmonds |
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| Institution: | (1) Department of Biochemistry, University of Nottingham Medical School, Queen's Medical Centre, NG7 2UH Nottingham, UK;(2) Present address: Department of Life Sciences, Trent Polytechnic, NG11 8NS Clifton, Nottingham, UK |
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| Abstract: | Two heart muscarinic responses are compared, the reduction of cyclic AMP concentration and the hydrolysis of phosphoinositides. It is suggested that the former is more important physiologically, since the latter is a slow response requiring much higher agonist concentrations. Inositol trisphosphate released from phosphoinositides is unlikely to produce a positive inotropic effect by releasing calcium from the sarcoplasmic reticulum. However, long term muscarinic effects may involve activation of protein kinase C by diacylglycerol released from phosphoinositides. |
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| Keywords: | muscarinic receptor heart phosphoinositide kinase C inositol trisphosphate cyclic AMP |
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