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APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway
Authors:Kenyi Saito-Diaz  Hassina Benchabane  Ajit Tiwari  Ai Tian  Bin Li  Joshua J. Thompson  Annastasia S. Hyde  Leah M. Sawyer  Jeanne N. Jodoin  Eduardo Santos  Laura A. Lee  Robert J. Coffey  R. Daniel Beauchamp  Christopher S. Williams  Anne K. Kenworthy  David J. Robbins  Yashi Ahmed  Ethan Lee
Affiliation:1. Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA;2. Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA;3. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA;4. Molecular Oncology Program, Division of Surgical Oncology, Dewitt Daughtry Family Department of Surgery, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA;5. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA;6. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA;7. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA;8. Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA;9. Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Abstract:
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  • Keywords:Wnt signaling  APC  LRP6  β-catenin  endocytosis  clathrin  caveolin  colorectal cancer
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