首页 | 本学科首页   官方微博 | 高级检索  
     


Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma
Authors:Daniel J. Merk  Jasmin Ohli  Natalie D. Merk  Venu Thatikonda  Sorana Morrissy  Melanie Schoof  Susanne N. Schmid  Luke Harrison  Severin Filser  Julia Ahlfeld  Serap Erkek  Kaamini Raithatha  Thomas Andreska  Marc Weißhaar  Michael Launspach  Julia E. Neumann  Mehdi Shakarami  Dennis Plenker  Ulrich Schüller
Affiliation:1. Center for Neuropathology, Ludwig-Maximilians-University, 81377 Munich, Germany;2. Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;3. Neurobiology, Harvard Medical School, Boston, MA 02215, USA;4. Munich Center for Integrated Protein Science at the Chemistry Department, Technical University, 85747 Munich, Germany;5. Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;6. Arthur and Sonia Labatt Brain Tumour Research Centre and Division of Neurosurgery, Hospital for Sick Children (HSC), Toronto, ON M5G 1L7, Canada;7. Program in Developmental and Stem Cell Biology, HSC, Toronto, ON M5G 1X8, Canada;8. Research Institute Children''s Cancer Center Hamburg, Martinistrasse 52, N63 (HPI), Hamburg 20251, Germany;9. Department of Neuropathology, University Medical Center Göttingen, 37099 Göttingen, Germany;10. German Center for Neurodegenerative Diseases (DZNE), Ludwig-Maximilians-University, 81377 Munich, Germany;11. Division of Clinical Pharmacology, Department of Internal Medicine IV, Ludwig-Maximilians-University, 80337 Munich, Germany;12. European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany;13. German Cancer Consortium (DKTK), Core Center Heidelberg, 69120 Heidelberg, Germany;14. Microarray and Deep-Sequencing Core Facility, University Medical Center Göttingen, 37077 Göttingen, Germany;15. Institute for Clinical Neurobiology, University of Würzburg, 97078 Würzburg, Germany;16. Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, 20246 Hamburg, Germany;17. Walter Brendel Center of Experimental Medicine, Ludwig-Maximilians-University, 81377 Munich, Germany;18. Department of Translational Genomics, University of Cologne, 50931 Cologne, Germany;19. Canada''s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC VSZ 4S6, Canada;20. Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1, Canada;21. Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, 55128 Mainz, Germany;22. Institute of Clinical Radiology, Ludwig-Maximilians-University, 81377 Munich, Germany;23. Department of Pediatric Neuroradiology, Istituto Giannina Gaslini, 16147 Genova, Italy;24. Institute of Human Genetics, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany;25. Institute for Human Genetics, Ulm University and Ulm University Medical Center, 89081 Ulm, Germany;26. Institute of Pathology, Ludwig-Maximilians-University, 81377 Munich, Germany;27. Division of Neuropathology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA;28. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada;29. Department of Pediatric Hematology and Oncology, University Hospital Heidelberg, 69120 Heidelberg, Germany;30. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada;31. Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, 20246 Hamburg, Germany
Abstract:
/><ol class=
  • Download high-res image (222KB)
  • Download full-size image
  • Keywords:acetyltransferase  cerebellum  Rubinstein-Taybi syndrome  SHH medulloblastoma  development
    本文献已被 ScienceDirect 等数据库收录!
    设为首页 | 免责声明 | 关于勤云 | 加入收藏

    Copyright©北京勤云科技发展有限公司  京ICP备09084417号