Two new scorpionates vanadium haloperoxidases model complexes: synthesis and structure of VO(O2)(pzH)(HB(pz)3) and VO(O2)(pzH)(B(pz)4) (pzH = pyrazole(C3H4N2)) |
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Authors: | Xing Yongheng Zhang Yuanhong Sun Zheng Ye Ling Xu Yongting Ge Maofa Zhang Baoli Niu Shuyun |
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Affiliation: | Bioinorganic Laboratory, Liaoning Normal University, Dalian 116029, PR China. yhxing2000@yahoo.com |
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Abstract: | Using vanadate, poly(1H-pyrazol-1-yl)borate and pyrazole as starting materials, two new neutral peroxovanadium(V) complexes with poly(1H-pyrazol-1-yl)borate, VO(O(2))(pzH)(HB(pz)(3))(1) and VO(O(2))(pzH)(B(pz)(4))(2), were synthesized successfully. Both complexes were characterized by elemental analysis, IR, UV-vis and NMR spectra. And the structure of complex 1 was determined by X-ray diffraction, which is somewhat relevant for haloperoxidase enzymes. Cytotoxic effects also are discussed on 3T3 cell proliferation. In the concentration range (0.1-100mumol), both complexes have an inhibiting cellular proliferation effect. When the cells cultivated with the complexes at high dose, the toxicity effect of both complexes is more and more predominant. |
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Keywords: | Peroxovanadium(V) complexes Haloperoxidases Poly(1H-pyrazol-1-yl)borate Crystal structure |
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