Enhancement of endothelial progenitor cell numbers and migration by H1152, a Rho kinase specific inhibitor |
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| Authors: | O Eunju Lee Seung Woo Lee Hyun-Sun Lim Hee-Suk Ahn Hyun-Young Shin Jong-Chul Kim Yonggoo Joe Young Ae |
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| Institution: | Cancer Research Institute and Department of Medical Lifescience, College of Medicine, The Catholic University of Korea, Seoul, Korea. |
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| Abstract: | Endothelial progenitor cells (EPCs) are applied in the treatment of ischemic diseases. In ex vivo culture of human cord-blood derived EPCs, H1152, (S)-(+)-2-methyl-1-(4-methyl-5-iso-quinolinyl) sulfonyl]-homopiperazine, markedly increased the number of EPCs. It also induced EPC migration, stimulated the phosphorylation of AKT, and reduced the expression of p27 in the EPCs. Thus H1152 can be used effectively in ex vivo expansion of EPCs. |
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