Modulation of c-myc and c-fos gene expression in regenerating rat liver by 2-mercaptopropionylglycine |
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Authors: | Ohri Sujata Sharma Dipali Dixit Aparna |
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Affiliation: | Gene Regulation Laboratory, Centre for Biotechnology, Jawaharlal Nehru University, New Delhi, India. |
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Abstract: | Expression of the two proto-oncogenes, c- myc and c- fos, in proliferating liver, and the modulation of their expression by 2-mercaptopropionylglycine (MPG) has been investigated. A significant increase in the expression of both c-myc and c-fos was observed, attaining a peak at 30 min, followed by a gradual decline for 8h after partial hepatectomy. Treatment of partially hepatectomized animals with MPG resulted in a significant decrease in the expression of both genes, the decrease being more marked in c- myc mRNA levels. At later time points, there was a very small rise in the mRNA levels of these genes in MPG-treated animals but they still remained much lower than the peak levels observed in both genes 30 min after surgery. A decline in the recovery of liver weight in MPG-treated animals was also observed. |
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Keywords: | regenerating liver MPG c‐ myc c‐ fos |
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