Pulse-driven magnetoimpedance sensor detection of biomagnetic fields in musculatures with spontaneous electric activity |
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Authors: | Nakayama Shinsuke Atsuta Satoshi Shinmi Takao Uchiyama Tsuyoshi |
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Institution: | School of Engineering, University of California, Santa Cruz, 1156 High St., Santa Cruz, CA 95064, USA. |
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Abstract: | We describe analysis and control of 50S ribosomal subunits by a solid-state 45nm diameter nanopore incorporated in a microfluidic chip. When used as a resistive pulse sensor, translocation of single 50S subunits through the nanopore produces current blockades that have a linear dependence on applied voltage. Introduction of individual subunits into the fluidic channel shows a threshold behavior that allows controlled entry of individual 50S ribosomal subunits. The incorporation of nanopores into a larger optofluidic chip system opens possibilities for electrical and optical studies of single ribosomes in well-defined and rapidly variable chemical environments. |
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