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Evidences for complex formation between L-dabPNA and aegPNA |
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| Authors: | Roviello Giovanni N Musumeci Domenica Bucci Enrico M Castiglione Mariangela Cesarani Annalisa Pedone Carlo Piccialli Gennaro |
| Institution: | aIstituto di Biostrutture e Bioimmagini—CNR, via Mezzocannone 16, I-80134 Napoli, Italy;bBionucleon srl, via D. Montesano 49, I-80131 Napoli, Italy;cBioindustrypark del Canavese, via Ribes 5, I-10010 Colleretto Giacosa (TO), Italy;dDipartimento di Chimica delle Sostanze Naturali, Università “Federico II”, via D. Montesano 49, I-80131 Napoli, Italy |
| Abstract: | Continuing our research on the development of nucleopeptides as ODN analogs for biomedical and bioengineering applications, here we report the synthesis and the chemical–physical characterization of a homoadenine hexamer based on a l-diaminobutyric acid (l-DABA) backbone (dabPNA), and its binding studies with a complementary aegPNA. We demonstrated by CD and UV experiments that the l-dabPNA binds the aegPNA forming a complex with good thermal stability, that we identified as a left-handed triplex. |
| Keywords: | l-dabPNA" target="_blank">l-dabPNA aegPNA Triplex CD Chirality |
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