Evolution of the noncoding regions inDrosophila mitochondrial DNA: Two intergenic regions |
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Authors: | Kazuko Komiya Takashi Kondoh Tadashi Aotsuka |
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Institution: | (1) Department of Biology, Tokyo Metropolitan University, Hachiohji-shi, 192-03 Tokyo, Japan |
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Abstract: | The sequences of the mitochondrial DNA (mtDNA) segment containing the two intergenic regions were determined for six species belonging to theDrosophila immigrans species group and compared to the corresponding segments ofDrosophila species which had been studied previously. We found remarkable differences in the evolutionary rates of the two intergenic regions. The Intergenic I region, which lies between thetRNA
gln
and thetRNA
ile
genes, was found to be highly conserved in terms of both size (30 ntp) and nucleotide sequence among the species studied. In contrast, the sequences of the Intergenic II region, which lies between thetRNA
f-met
and thetRNA
ile
genes, showed considerable variation. The size of the Intergenic II region ranged from 0 to 88 ntp, and accurate alignment was possible only among sequences from geographical strains or very closely related species in thenasuta species subgroup. The observed differences in conservation of the two mtDNA intergenic regions are discussed in light of functional constraints on mtDNA sequences. |
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Keywords: | mitochondrial DNA Drosophila noncoding intergenic region |
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