Solutes in small amounts provide for lipid-bilayer softness: cholesterol,short-chain lipids,and bola lipids |
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Authors: | Jesper Lemmich Thomas Hønger Kell Mortensen John Hjort Ipsen Rogert Bauer O. G. Mouritsen |
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Affiliation: | Department of Chemistry, The Technical University of Denmark, Building 206, DK-2800 Lyngby, Denmark, (Fax: +45-45-934808; e-mail: ogm@kemi.dtu.dk), DK Department of Solid State Physics, Ris? National Laboratory, DK-4000 Roskilde, Denmark, DK Department of Physics, Royal Danish Agricultural and Veterinary University, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark, DK
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Abstract: | The effect of the incorporation of small amounts (∼1 mole%) of amphiphilic solutes, such as cholesterol, a short-chain lipid (DC10PC), and a bola lipid, into multilamellar DMPC bilayers is studied by small-angle neutron scattering and differential-scanning calorimetry. The anomalous swelling behavior observed in the transition region of pure DMPC bilayers is interpreted as an indication of bilayer softening and thermally reduced bending rigidity. Small amounts of the solutes are found to maintain or even enhance the bilayer softness. In the case of cholesterol, a systematic study shows that the well-known rigidification effect is observed only for cholesterol concentrations above 3–4 mole%. The results are discussed in relation to the physical properties of internal cell membranes. Received: 28 May 1996 / Accepted: 27 July 1996 |
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Keywords: | Lipid bilayer Softness Swelling Cholesterol Short-chain lipid Bola lipid Small-angle neutron scattering Calorimetry |
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