环氧合酶-2在胃癌中的研究进展

我国胃癌发病人数居全球首位,其发生机制及安全有效的治疗是研究重点。大量研究结果表明,环氧化酶-2(Cyclooxygenase-2,COX-2)过度表达促进肿瘤细胞增殖和抑制细胞凋亡,并与胃癌的发生发展、淋巴转移、分化程度、病理分期及预后密切相关。随着COX-2与胃癌关系的研究的深入,COX-2已逐渐成为胃癌治疗的新的靶点。近年来,针对细胞受体、信号传导、细胞周期和血管生成等靶点的抗肿瘤治疗已成为肿瘤治疗研究的新方向。因此,以COX-2为特异靶点的治疗策略有望为胃癌治疗提供新的思路。

Research Advances in Cyclooxygenase-2 and Gastric Carcinoma

The population of patients with gastric carcinoma in China ranks first in the world. A safe and effective treatment ofgastric carcinoma is the key point in the research. Several studies have shown that Cyclooxygenase-2 (COX-2) overexpression promotestumor cell proliferation and inhibition of apoptosis. COX-2 is closely associated with the development of gastric carcinoma, lymph nodemetastasis, differentiation, pathological staging and prognosis. COX-2 has become a new target for cancer therapy with COX-2 andgastric carcinoma in-depth study. In recent years, along with the molecular biology of cancer occurrence and development mechanism ofthe deepening of the research, directed cell receptor, signal transduction, cell cycle and angiogenesis targeted anti tumor therapy hasbecome a new research direction in tumor therapy. Therefore, COX-2, as a specific target for therapeutic strategies for the treatment ofgastric carcinoma, is expected to provide new ideas.