Selenium in total parenteral nutrition |
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Authors: | H B von Stockhausen |
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Institution: | 1. Universitaets-Kinderklinik, University of Wuerzburg, D-8700, Wuerzburg, Federal Republic of Germany
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Abstract: | In clinical practice, selenium deficiency may arise under conditions of chronic malnutrition and especially after long-term
total parenteral nutrition (TPN). In infants receiving long-term TPN, we observed plasma selenium levels as low as those previously
reported in Chinese children with Keshan disease. Low plasma selenium levels were also usually associated with very low activities
of glutathione peroxidase. Although clinical symptoms of selenium deficiency did not occur in our patients, several cases
have been described in the literature, indicating the need for supplementation in TPN. In order to derive at the appropriate
dosage, it is proposed to correlate it with the total protein supply. According to our present knowledge, .5–1.0 μg selenium/g
of protein appears to be adequate to keep patients in Se balance. For Se repletion of body stores, this dosage has been increased
up to 3 μg of Se/g of protein. Advantages and disadvantages of selenite and of selenomethionine as possible supplemental forms
of Se for TPN solutions are discussed. |
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Keywords: | Index Entries" target="_blank">Index Entries Parenteral nutrition selenium deficiency glutathione peroxidase selenium substitution selenite selenomethionine |
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