Affiliation: | aFaculty of Science, Chemistry Department, Horvatovac 102a, 10000 Zagreb, Croatia bDivision of Organic Chemistry and Biochemistry, Ruđer Bošković Institute Zagreb, Croatia cDivision of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia |
Abstract: | The paper describes synthesis of several novel thiosemicarbazone derivatives. Furthermore, crystal and molecular structure of 4-diethylamino-salicylaldehyde 4-phenylthiosemicarbazone revealed planarity of conjugated aromatic system, which suggested the possibility of DNA binding by intercalation, especially for here studied naphthalene derivatives. However, here presented DNA binding studies excluded this mode of action. Physicochemical and structural properties of novel derivatives were compared with previously studied analogues, taken as reference compounds, revealing distinctive differences. In addition, novel thiosemicarbazone derivatives (1, 2 and 5–8) clearly display stronger antiproliferative activity on five tumor cell lines than the reference compounds 3 and 4, which supports their further investigation as potential antitumor agents. |