Viral trans-dominant manipulation of algal sphingolipids |
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Authors: | Michaelson Louise V Dunn Teresa M Napier Johnathan A |
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Institution: | 1 Department of Biological Chemistry, Rothamsted Research, Harpenden, Herts AL5 2JQ, UK;2 Biochemistry Department, Uniformed Services University of the Health Sciences, Bethesda, MA 20814, USA |
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Abstract: | Emiliania huxleyi is the host for the coccolithovirus (EhV), which is responsible for the demise of large oceanic blooms formed by this alga. The EhV-86 virus genome sequence has identified several genes apparently involved in sphingolipid metabolism. Recently, an unusual glucosylceramide from E. huxleyi infected with EhV-86 was isolated, implicating sphingolipids in the lysis of this alga. However, the EhV-86-encoded genes contain only a subset of the activities required to generate the novel sphingolipid, implying that its synthesis is the result of coordinated interactions between algal- and viral-encoded biosynthetic enzymes. Here, we discuss the likely role for EhV-86 open reading frames (ORFs) in the synthesis of novel sphingolipids and also consider the concept of the trans-dominant manipulation of lipid metabolism. |
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