Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis |
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| Authors: | Constanze Csaki Ali Mobasheri Mehdi Shakibaei |
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| Institution: | (1) Musculoskeletal Research Group, Institute of Anatomy, Ludwig-Maximilians-University Munich, Pettenkoferstrasse 11, 80336 Munich, Germany;(2) Musculoskeletal Research Group, Division of Veterinary Medicine, School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, University of Nottingham, Sutton Bonington Campus, LE12 5RD Sutton Bonington, UK |
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| Abstract: | Introduction Currently available treatments for osteoarthritis (OA) are restricted to nonsteroidal anti-inflammatory drugs, which exhibit
numerous side effects and are only temporarily effective. Thus novel, safe and more efficacious anti-inflammatory agents are
needed for OA. Naturally occurring polyphenolic compounds, such as curcumin and resveratrol, are potent agents for modulating
inflammation. Both compounds mediate their effects by targeting the NF-κB signalling pathway. |
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