Adoptive transfer of delayed-type hypersensitivity to sendai virus |
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Authors: | H C J Ertl |
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Institution: | (1) Department of Microbiology, John Curtin School of Medical Research, Australian National University, 2601 Canberra, A. C. T., Australia |
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Abstract: | TheH-2 restriction pattern of cytolytic T lymphocytes (Tc) and T lymphocytes which mediate a delayed-type hypersensitivity response (Td) directed against infectious Sendai virus was investigated usingH-2 mutant mice. Td and Tc lymphocytes exhibit the same fine specificity for self-recognition, for example, B6.C-H- 2bm1 effector T cells were unable to recognize viral antigens in association with wild-type Kb and vice versa, B6.-H- 2bm6 effector cells did not mediate a reaction against virus plus wild-type Kb but, on the other hand, T cells of wild-type Kb recognized virus plus Kbm6.BALB/c-H- 2dm2 T cells lacked reactivity against virus in association with wild-type Dd, but again wild-type Dd effector cells recognized virus plus Ddm2.Abbreviations used in this paper DTH
delayed-type hypersensitivity
- EID50
mean egg infective dose
- FCS
fetal calf serum
- HAU
hemagglutinating units
- LPS
lipopolysaccharide
- Ly(–)
low amount of Ly antigens
- MHC
major histocompatibility complex
- 2-ME
2-mercaptoethanol
- PBS
phosphate-buffered saline
- Tc
cytolytic T cell
- Td
T cell which mediates a delayed-type hypersensitivity reaction |
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