Regulation of hapten-specific T-cell response. II. Functional analysis of helper T cells and cytotoxic T cells in animals suppressed by azobenzenearsonate (ABA)-specific suppressor T cells |
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| Authors: | C F Scott M Tsurufuji S J Naides M S Sy |
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| Affiliation: | 1. School of Mental Health, Zhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325035, PR China;2. Department of General Psychiatric, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 311122, PR China;3. Second Clinical Medicine Faculty, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China;4. Department of Clinical Psychology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310005, PR China;1. Centre de Biophysique Moléculaire, CNRS UPR4301, F-45071, Orléans cedex 02, France;2. Inserm UMS 55 ART ARNm and University of Orléans, F-45100 Orléans;3. Institut Universitaire de France, 1 rue Descartes, F-75035 Paris, France;4. Sanofi R&D, Integrated Drug Discovery, F-94400 Vitry-sur-Seine, France;5. Immunity and Cancer Team, Onco-Hemato Immuno-Onco Department, OHIO, Cancer Research Centre of Marseille, CRCM, Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, F-13273 Marseille, France;6. Inserm U 1310 F-94800 Villejuif and CITHERA/ UMS45 Infrastructure INGESTEM, F-91100, Evry, France;7. University Paris Saclay, APHP Paul Brousse Hospital, School of Medicine, F-94270 Le Kremlin Bicêtre, France |
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| Abstract: | The administration of azobenzenearsonate-modified syngeneic spleen cells (ABA-SC) intravenously induces a population of first order hapten-specific inducer suppressor T cells (Ts1), which downregulate various aspects of T-cell-mediated immune responses via a well defined suppressor-T-cell pathway. In this study, we investigated the effects of these suppressor cells on the generation of ABA-specific cytolytic T lymphocytes (CTL) and helper T cells (Th) in vivo. We found evidence for functional impairment of ABA-activated Th and ABA-specific CTL precursors (CTLp) in the suppressed animals by a number of different in vitro criteria. Functional analysis of ABA-specific CTLp and ABA-activated Th in suppressed animals revealed that ABA-specific Ts inhibit the generation of CTL by impairing the antigen-specific activation of Th, which may in turn, prevent the clonal expansion of antigen-specific CTLp. The significance of these findings in relationship to our understanding of the cellular interactions necessary for the generation of CTL and the mode of action and mechanisms of suppressor T cells is discussed. |
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