| Institution: | (1) Lovelace Respiratory Research Institute, Albuquerque, NM, USA;(2) Department of Otolaryngology, University of Colorado Health Sciences Center, Denver, CO, USA;(3) NIEHS Marine and Freshwater Biomedical Sciences Center, University of Miami, Miami, FL, USA;(4) National Center for Environmental Health, Center for Disease Control and Prevention, Atlanta, GA, USA;(5) Center for Marine Science Research, University of North Carolina at Wilmington, Wilmington, NC, USA;(6) Research Service (151), Jerry Pettis Memorial Veterans Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA |
| Abstract: | Brevetoxin-3 was shown previously to adversely affect central auditory function in goldfish. The present study evaluated the effects of exposure to this agent on cochlear function in mice using the 2f1-f2 distortion-product otoacoustic emission (DPOAE). Towards this end, inbred CBA/CaJ mice were exposed to a relatively high concentration of brevetoxin-3 (~400  g/m3) by nose-only inhalation for a 2-h period. Further, a subset of these mice received a second exposure a day later that lasted for an additional 4 h. Mice exposed only once for 2 h did not exhibit any notable cochlear effects. Similarly, mice exposed two times, for a cumulative dose of 6 h, exhibited essentially no change in DPOAE levels. |
