Hyperuricemia and metabolic syndrome in children with overweight and obesity |
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| Authors: | Soralla Civantos Modino M Guadalupe Guijarro de Armas Susana Monereo Mejías July M Montaño Martínez Paloma Iglesias Bolaños María Merino Viveros Jose María Ladero Quesada |
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| Institution: | 1. Endocrinology and Nutrition, Getafe University Hospital, Madrid, Spain;2. Gastroenterology, San Carlos University Hospital, Madrid, Spain;1. Servicio de Endocrinología, Hospital Universitario de Getafe, Getafe, Madrid, Spain;2. Servicio de Medicina Nuclear, Hospital Universitario de Getafe, Getafe, Madrid, Spain;1. Department of Cardiology, Kasugai Municipal Hospital, 1-1-1 Takaki-cho, Kasugai, Aichi 486-8510, Japan;2. Department of Cardiovascular Medicine, Inabe General Hospital, 771 Ageki, Hokusei-cho, Inabe, Mie 511-0428, Japan;3. Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, 5-161 Maebata-cho, Tajimi, Gifu 507-0042, Japan;4. Department of Internal Medicine, Meitoh Hospital, 3-1911 Kamiyashiro, Meito-ku, Nagoya, Aichi 465-0025, Japan;5. Department of Biostatistics, Graduate School of Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan;6. Department of Computer Science, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, Aichi 466-8555, Japan;7. Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan;8. Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima-machiya, Tsu, Mie 514-8507, Japan;1. Pediatric and Infectious Disease Unit, Bambino Gesù Children''s Hospital-IRCCS, Rome, Italy;2. Hepato-Metabolic Disease Unit, Bambino Gesù Children''s Hospital-IRCCS, Rome, Italy;3. Molecular Genetics of Complex Phenotypes Research Unit, Bambino Gesù Children''s Hospital-IRCCS, Rome, Italy;4. Department of Pediatrics, Sapienza University of Rome, Rome, Italy;5. Medical Directorate, Bambino Gesù Children''s Hospital-IRCCS, Rome, Italy;6. Laboratory of Medical Genetics, Bambino Gesù Children''s Hospital-IRCCS, Rome, Italy |
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| Abstract: | ObjectiveTo study the prevalence of hyperuricemia in children with overweight or obesity and analyze the relation with metabolic syndrome and the diseases that define it.Materials and methodsThis is a cross-sectional prevalence study in 148 children recruited from pediatric endocrinology consultation, with overweight or obesity (12 ± 3 years, 48% boys, BMI 31.8 ± 6.1). We measured BMI, waist-height, waist circumference, blood pressure with standard instrumentation and glucose (fasting and after overload with 75 g), insulin resistance, cholesterol HDL, triglycerides and uric acid.ResultsThe prevalence of hyperuricemia was 53%. Patients with hyperuricemia had greater BMI (33.9 vs 30.6, p = 0.003), plus waist circumference (101.4 vs 91.1 cm, p < 0.001), higher blood pressure: systolic (123.4 vs 111.9 mm Hg, p < 0.001), diastolic (78.2 vs 68.7 mm Hg, p < 0.001). They presented greater blood glucose after overload oral glucose (107.5 vs 100.7 mg/dl, p = 0.03), insulin was higher (29.2 vs 20.7 mg/dl, p = 0.001) as well as HOMA IR (6.5 vs 4.4, p < 0.001) and HDL levels were lower (49.5 vs 54.4 mg/dl, p = 0.02).Uric acid's level which most is the likely diagnosis of metabolic syndrome corresponds to 5.4 mg/dl in our sample (sensitivity: 64% and specificity 62%).ConclusionThe prevalence of hyperuricemia in children with overweight and obesity is high. In the group of patients with obesity and hyperuricemia, we found out that the parameters measured to diagnose with metabolic syndrome were less favorable. Uric acid's level from where there is a higher possibility to see metabolic syndrome is 5.4 mg/dl. |
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