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An Exceptionally Potent Inducer of Cytoprotective Enzymes: ELUCIDATION OF THE STRUCTURAL FEATURES THAT DETERMINE INDUCER POTENCY AND REACTIVITY WITH Keap1* |
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| Authors: | Albena T Dinkova-Kostova Paul Talalay John Sharkey Ying Zhang W David Holtzclaw Xiu Jun Wang Emilie David Katherine H Schiavoni Stewart Finlayson Dale F Mierke Tadashi Honda |
| Institution: | From the ‡Biomedical Research Institute, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom.;the §Lewis B. and Dorothy Cullman Chemoprotection Center and the Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and ;the ¶Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755 |
| Abstract: | |
| Keywords: | Drug Action Drug Design Gene Expression Oxidation-Reduction Oxidative Stress Keap1 NQO1 Nrf2 Chemoprevention Electrophile Signal |