Luminal Mg2+, a key factor controlling RYR2-mediated Ca2+ release: cytoplasmic and luminal regulation modeled in a tetrameric channel |
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| Authors: | Laver Derek R Honen Bonny N |
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| Institution: | School of Biomedical Sciences, University of Newcastle and Hunter Medical Research Institute, Callaghan, NSW 2308, Australia. Derek.Laver@newcastle.edu.au |
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| Abstract: | In cardiac muscle, intracellular Ca2+ and Mg2+ are potent regulators of calcium release from the sarcoplasmic reticulum (SR). It is well known that the free Ca2+] in the SR (Ca2+]L) stimulates the Ca2+ release channels (ryanodine receptor RYR]2). However, little is known about the action of luminal Mg2+, which has not been regarded as an important regulator of Ca2+ release. |
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