Effect of zinc on cadmium influx and toxicity in cultured CHO cells |
| |
| Authors: | P. C. Huang Betty Smith Patricia Bohdan Alice Corrigan |
| |
| Affiliation: | (1) Department of Biochemistry, The Johns Hopkins University, School of Hygiene and Public Health, 615 North Wolfe Street, 21205 Baltimore, Maryland |
| |
| Abstract: | Addition of zinc lowers the toxicity level of cadmium in cultured CHO cells. Cell survival and protein synthesis were used to measure the cellular toxicity of cadmium.109Cd was used to measure cadmium uptake by the cells. The results suggest that these class IIB transition metals, zinc and cadmium, share a common transport mechanism. Thus, the antagonism appears to involve a reduction in the influx of cadmium due to the presence of zinc. |
| |
| Keywords: | Cadmium, influx and zinc in CHO cells toxicity and zinc in CHO cells zinc, and cadmium influx and toxicity in CHO cells antagonism, between zinc and cadmium in CHO cells transport, of zinc and cadmium in CHO cells CHO cells, zinc and cadmium in metallothionein, and zinc/cadmium toxicity in CHO cells |
| 本文献已被 SpringerLink 等数据库收录！ |
|
