Fronto-cortical regulation of beta-endorphin actions in the rat |
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Authors: | S Itoh G Katsuura |
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Institution: | Shionogi Research Laboratories, Fukushima-ku, Osaka 553, Japan |
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Abstract: | Ablation of the frontal neocortex markedly enhanced the antinociceptive and cataleptic actions of beta-endorphin injected into the lateral ventricle of rat brain. This enhanced response was not affected by simultaneous administration of cholecystokinin octapeptide (CCK-8). In sham-operated rats, however, CCK-8 suppressed the effects of beta-endorphin in a dose-related manner. Moreover, ablation of a similar amount of occipital neocortex did neither affect beta-endorphin actions nor the interactions of CCK-8. |
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Keywords: | Frontal cortex Occipital cortex β-Endorphin Antinociception Catalepsy Cholecystokinin octapeptide |
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