| 环境中抗生素抗性基因与I型整合子的研究进展 |
| |
| 引用本文： | 苏志国,张衍,代天娇,陈嘉瑜,张永明,温东辉.环境中抗生素抗性基因与I型整合子的研究进展[J].微生物学通报,2018,45(10):2217-2233. |
| |
| 作者姓名： | 苏志国 张衍 代天娇 陈嘉瑜 张永明 温东辉 |
| |
| 作者单位： | 北京大学环境科学与工程学院;江南大学环境与土木工程学院;上海师范大学生命与环境科学学院 |
| |
| 基金项目： | 国家自然科学基金(51678003，51529801，51708253) |
| |
| 摘 要： | 抗生素抗性基因(Antibiotic resistance genes,ARGs)作为一种新型污染物在不同环境中广泛分布、来源复杂,对生态环境和人类健康造成了很大的潜在风险。同时,Ⅰ型整合子(Int Ⅰ)介导的ARGs水平转移是环境中微生物产生耐药性的重要途径,Ⅰ型整合子整合酶基因(intI1)与ARGs丰度在环境中表现出了较高的正相关性,Int Ⅰ可以作为标记物在一定程度上反映ARGs在环境中的迁移转化规律和人类活动影响程度。本文介绍ARGs与Int Ⅰ在环境中的来源与分布,总结Int Ⅰ介导的ARGs迁移转化机制以及相关研究方法,并展望未来的研究发展趋势。
|
| 关 键 词： | 抗生素抗性基因，I型整合子，基因盒，水平基因转移，传播 |
Antibiotic resistance genes and class 1 integron in the environment: research progress |
| |
| SU Zhi-Guo,ZHANG Yan,DAI Tian-Jiao,CHEN Jia-Yu,ZHANG Yong-Ming and WEN Dong-Hui.Antibiotic resistance genes and class 1 integron in the environment: research progress[J].Microbiology,2018,45(10):2217-2233. |
| |
| Authors: | SU Zhi-Guo ZHANG Yan DAI Tian-Jiao CHEN Jia-Yu ZHANG Yong-Ming and WEN Dong-Hui |
| |
| Institution: | 1. College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China,2. School of Environment and Civil Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China,1. College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China,3. College of Life and Environmental Sciences, Shanghai Normal University, Shanghai 200234, China,3. College of Life and Environmental Sciences, Shanghai Normal University, Shanghai 200234, China and 1. College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China |
| |
| Abstract: | As a new type of pollutant, antibiotic resistance genes (ARGs) come from complicated sources and distribute widely in different habitats to pose a great potential risk to ecological environment and human health. Meanwhile, class 1 integron plays an important role in ARGs horizontal transfer among environmental bacteria and turns them into antibiotic resistant bacteria (ARB). The abundance of intI1 and ARGs in the environment shows a significant positive-correlation, therefore Int I might be used as a molecular marker to indicate the mechanism of ARGs transfer and transformation in the environment and reflect the impact of human activities. In this paper, we introduce the sources and distribution of ARGs and Int I in the environment, review the dissemination mechanisms of ARGs via Int I and related research methods, and predict the future research trends based on the current research progress. |
| |
| Keywords: | antibiotic resistance genes class 1 integron gene cassette horizontal gene transfer dissemination |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《微生物学通报》浏览原始摘要信息 |
| 点击此处可从《微生物学通报》下载免费的PDF全文 |
|
