| 肠杆菌科细菌的Rcs信号转导系统——毒力、应激 |
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| 引用本文： | 叶立娜,瞿涤.肠杆菌科细菌的Rcs信号转导系统——毒力、应激[J].微生物与感染,2018,13(2):114-121. |
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| 作者姓名： | 叶立娜 瞿涤 |
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| 作者单位： | 复旦大学基础医学院病原生物学系，医学分子病毒学教育部/卫生部重点实验室，上海 200032 |
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| 基金项目： | 国家自然科学基金(81571955) |
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| 摘 要： | Rcs是肠杆菌科细菌中的一种复杂的双组分信号转导系统，能调节细菌荚膜异多糖酸合成，以及细菌鞭毛基因、抗酸性基因等的表达。Rcs不同于典型的双组分系统，其由3个蛋白构成，磷酸转移过程分3步进行。不同细菌中的Rcs功能有所区别，主要为调控细菌的毒力和应激。本文在简单介绍细菌双组分信号转导系统的基础上，重点对肠杆菌科细菌Rcs的组成、功能及磷酸转移机制进行综述。
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| 关 键 词： | 双组分信号转导系统 肠杆菌科 毒力 应激 |
Rcs signal transduction system in Enterobacteriacea bacteria: associated virulence and stress reaction |
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| YE Lina,QU Di.Rcs signal transduction system in Enterobacteriacea bacteria: associated virulence and stress reaction[J].Journal of Microbes and Infection,2018,13(2):114-121. |
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| Authors: | YE Lina QU Di |
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| Institution: | Department of Medical Microbiology and Parasitology, Key Laboratory of Medical Molecular Virology of Ministries of Education and Health，School of Basic Medical Sciences, Fudan University, Shanghai 200032, China |
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| Abstract: | Rcs is a complex two-component system in Enterobacteriaceae bacteria. It regulates the synthesis of bacterial colanic acids, and the expressions of bacterial flagella genes and resistance genes. Distinguished with typical two-component systems, Rcs consists of three components, among which phosphate group is transferred via three steps. Rcs in different species may possess its own distinct functions, mainly in the regulation of bacterial virulence and stress control. This review focuses on the components, function and signal transduction mechanisms of Rcs system. |
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| Keywords: | Two-component system Enterobacteriaceae Virulence Stress |
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