禽坦布苏病毒诱导的宿主免疫应答

禽坦布苏病毒(Avian Tembusu virus,ATMUV)是近年来在我国新发现的一种病毒,可感染多种蛋禽,感染动物临床特征为采食量下降,产蛋量骤减,甚至停产,感染后期呈神经症状,如腿和翅膀麻痹、共济失调等。ATMUV在我国多个省市地区流行,给我国甚至世界养禽业带来严重影响。固有免疫是机体抵抗病原感染的第一道重要防线,是机体与生俱来的抵御病原微生物的能力。适应性免疫是机体免疫系统在抗原刺激下产生特异性抗体及免疫效应细胞的过程,以建立针对某种病原微生物的抵抗力,是机体免疫系统的重要部分。本文将从禽坦布苏病毒诱导宿主固有免疫应答和适应性免疫应答两方面进行综述。

Host immune response induced by avian Tembusu virus infection

Avian Tembusu virus (ATMUV) is a highly pathogenic virus infecting variety kinds of laying birds, resulting in appetite decreases and significant reduction in egg production. At the last stage, the affected animals may have neurological symptoms, such as muscle paralysis and dystaxia. In recent years, ATMUV spreads quickly in many provinces in China and has caused huge economic loss in poultry industry all over the world. Host innate immunity is the first line to defend against the infection of pathogens at early stages. Innate immune response is the nature ability of the organism to fight against the pathogenic microorganisms. On the other hand, adaptive immunity is the process by which the immune system produces specific antibodies by B cells and cellular immune response by T cells. Adaptive immunity is the key components of host immune system that contribute to the resistance to pathogens and are the basis of immunization. In this review, we will discuss host immune response to ATMUV infection and highlight the mechanisms by which ATMUV induces the host innate and adaptive immunity.