Mechanisms of caspase activation and inhibition during apoptosis |
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| Authors: | Shi Yigong |
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| Affiliation: | Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, NJ 08544, USA. yshi@molbio.princeton.edu |
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| Abstract: | Caspases are central components of the machinery responsible for apoptosis. Recent structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome have revealed a conserved mechanism of caspase activation and inhibition. This article reviews these latest advances and presents our current understanding of caspase regulation during apoptosis. |
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